| Date | Location | Result | |
| 2-18/06 | Penn State Altoona Adler Gym | Penn State Altoona Lions 81, Medaille College 78 | Box score |
| 2/17/06 | Penn State Altoona Adler Gym | Penn State Altoona Lions 69, Hilbert College 63 | Box score |
| 02/14/06 | Frederick, Md - Gov. Thomas Johnson HS | Hood 76, Penn State Altoona Lions 60 | Box score |
| 02/11/06 | La Roche College | La Roche College 57, Penn State Altoona Lions 36 | Box score |
| 02/10/06 | Painesville, Ohio | Lake Erie College 73, Penn St.-Altoona 45 | Box score |
| 02/07/06 | Chambers Hall Gym, Greensburg, PA | Pitt Greensburg Bobcats 75, Penn State Altoona Lions 65 | Box score |
| 2/4/06 | Penn State Altoona Adler Gym | Penn State Altoona Lions 52, Penn State Behrend 50 | Box score |
| 2/3/06 | Penn State Altoona Adler Gym | BRFM4 56, Penn State Altoona Lions 53 | Box score |
| 01/31/06 | Frostburg, Md. | Penn State Altoona Lions 93, Frostburg State 71 | Box score |
| 01/28/06 | Cresson, PA | Mount Aloysius College-men 98, Penn State Altoona Lions 89 | Box score |
| 1/24/06 | Adler Athlc. Complex, Penn State Altoona | Pitt Greensburg 84, Penn State Altoona Lions 72 | Box score |
| 1/21/06 | Hafner Recreation Center | Hilbert College 75, Penn State Altoona 73 | Box score |
| 1/20/06 | Medaille College - Sullivan Center | Medaille College 64, Penn State Altoona 61 | |
| 1/17/06 | Penn State Altoona Adler Gym | Frostburg State University 67, Penn State Altoona Lions 64 | Box score |
| 1/14/06 | Penn State Altoona Adler Gym | Lake Erie College 77, Penn State Altoona Lions 66 | Box score |
| 1/13/06 | Penn State Altoona Adler Gym | La Roche College 61, Penn State Altoona Lions 48 | Box score |
| 1/7/06 | Pitt-Bradford | Pitt-Bradford 80, Penn State Altoona 63 | Box score |
| 1/06/06 | Erie, PA | Penn State Behrend 63, Penn State Altoona 55 | Box score |
| 12/10/05 | Penn State Altoona Adler Gym | Penn State Altoona Lions 75, Waynesburg College 70 | Box score |
| 12/3/05 | Penn State Altoona Adler Gym | Mount Aloysius College 86, Penn State Altoona Lions 80 | Box score |
| 11/30/05 | Penn State Altoona Adler Gym | Penn State Altoona Lions 68, Hood College 67 | Box score |
| 11/28/05 | Penn State Altoona Adler Gymnasium | Heidelberg College 93, Penn State Altoona Lions 77 | Box score |
| 11/22/05 | Penn State Altoona Adler Athletic Complx | Penn State Altoona Lions 69, Grove City College Wolverines 64 | Box score |
| 11/19/05 | Horsburgh Gymnasium, Cleveland, Ohio | Adrian College 81, PSU-Altoona 70 | Box score |
| 11/18/05 | Horsburgh Gymnasium, Cleveland, Ohio | Case Western Reserve Univ. 78, PSU-Altoona 72 | Box score |